2021-2020

2021

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in children and adolescents in Africa: A randomised, placebo-controlled, multicentre Phase II clinical trial.

Anywaine Z, Barry H, Anzala O, Mutua G, Sirima SB, Eholie S, Kibuuka H, Bétard C, Richert L, Lacabaratz C, McElrath MJ, De Rosa SC, Cohen KW, Shukarev G, Katwere M, Robinson C, Gaddah A, Heerwegh D, Bockstal V, Luhn K, Leyssen M, Thiébaut R, Douoguih M; EBL2002 Study group. PLoS Med. 2022 Jan 11;19(1):e1003865. doi: 10.1371/journal.pmed.1003865. eCollection 2022 Jan. PMID: 35015777

Risk factors associated with house entry of malaria vectors in an area of Burkina Faso with high, persistent malaria transmission and high insecticide resistance.

Yaro JB, Tiono AB, Sanou A, Toe HK, Bradley J, Ouedraogo A, Ouedraogo ZA, Guelbeogo MW, Agboraw E, Worrall E, Sagnon N’, Lindsay SW, Wilson AL. Malar J. 2021 Oct 10;20(1):397. doi: 10.1186/s12936-021-03926-5. PMID: 34629053

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in healthy and HIV-infected adults: A randomised, placebo-controlled Phase II clinical trial in Africa.

Barry H, Mutua G, Kibuuka H, Anywaine Z, Sirima SB, Meda N, Anzala O, Eholie S, Bétard C, Richert L, Lacabaratz C, McElrath MJ, De Rosa S, Cohen KW, Shukarev G, Robinson C, Gaddah A, Heerwegh D, Bockstal V, Luhn K, Leyssen M, Douoguih M, Thiébaut R; EBL2002 Study group. PLoS Med. 2021 Oct 29;18(10):e1003813. doi: 10.1371/journal.pmed.1003813. eCollection 2021 Oct. PMID: 34714820

Risk factors for Plasmodium falciparum infection in pregnant women in Burkina Faso: a community-based cross-sectional survey.

Yaro JB, Ouedraogo A, Diarra A, Sombié S, Ouedraogo ZA, Nébié I, Drakeley C, Sirima SB, Tiono AB, Lindsay SW, Wilson AL.Malar J. 2021 Sep 6;20(1):362. doi: 10.1186/s12936-021-03896-8.PMID: 34488770 Free PMC article.

Persistent Submicroscopic Plasmodium falciparum Parasitemia 72 Hours after Treatment with Artemether-Lumefantrine Predicts 42-Day Treatment Failure in Mali and Burkina Faso.

Beshir KB, Diallo N, Somé FA, Sombie S, Zongo I, Fofana B, Traore A, Dama S, Bamadio A, Traore OB, Coulibaly SA, Maurice OS, Diarra A, Kaboré JM, Kodio A, Togo AH, Dara N, Coulibaly M, Dao F, Nikiema F, Compaore YD, Kabore NT, Barry N, Soulama I, Sagara I, Sirima SB, Ouédraogo JB, Djimde A, Sutherland CJ.Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0087321. doi: 10.1128/AAC.00873-21. Epub 2021 Jul 16.PMID: 34060901

Extended follow-up of children in a phase2b trial of the GMZ2 malaria vaccine.

Dassah S, Adu B, Sirima SB, Mordmüller B, Ngoa UA, Atuguba F, Arthur FKN, Mensah BA, Kaddumukasa M, Bang P, Kremsner PG, Mategula D, Flach C, Milligan P, Theisen M.Vaccine. 2021 Jul 13;39(31):4314-4319. doi: 10.1016/j.vaccine.2021.06.024. Epub 2021 Jun 24.PMID: 34175127 Free article. Clinical Trial.

Safety and immunogenicity of Vi-typhoid conjugate vaccine co-administration with routine 9-month vaccination in Burkina Faso: A randomized controlled phase 2 trial.

Sirima SB, Ouedraogo A, Barry N, Siribie M, Tiono A, Nébié I, Konaté A, Berges GD, Diarra A, Ouedraogo M, Bougouma EC, Soulama I, Hema A, Datta S, Liang Y, Rotrosen ET, Tracy JK, Jamka LP, Oshinsky JJ, Pasetti MF, Neuzil KM, Laurens MB. Int J Infect Dis. 2021 Jul;108:465-472. doi: 10.1016/j.ijid.2021.05.061. Epub 2021 Jun 1. PMID: 34082090

Prevalence and predictors of vitamin D deficiency in young African children.

Mogire RM, Morovat A, Muriuki JM, Mentzer AJ, Webb EL, Kimita W, Ndungu FM, Macharia AW, Cutland CL, Sirima SB, Diarra A, Tiono AB, Lule SA, Madhi SA, Sandhu MS, Prentice AM, Bejon P, Pettifor JM, Elliott AM, Adeyemo A, Williams TN, Atkinson SH.BMC Med. 2021 May 20;19(1):115. doi: 10.1186/s12916-021-01985-8.PMID: 34011341 Free PMC article.

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.

Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H; FALCI Study Group. Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4. PMID: 34011358

Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections.

Barry A, Bradley J, Stone W, Guelbeogo MW, Lanke K, Ouedraogo A, Soulama I, Nébié I, Serme SS, Grignard L, Patterson C, Wu L, Briggs JJ, Janson O, Awandu SS, Ouedraogo M, Tarama CW, Kargougou D, Zongo S, Sirima SB, Marti M, Drakeley C, Tiono AB, Bousema T.Nat Commun. 2021 Apr 26;12(1):2443. doi: 10.1038/s41467-021-22573-7.PMID: 33903595 Free PMC article.

Maintaining Plasmodium falciparum gametocyte infectivity during blood collection and transport for mosquito feeding assays in the field.

Soumare HM, Guelbeogo WM, van de Vegte-Bolmer M, van Gemert GJ, Soumanaba Z, Ouedraogo A, Ouattara MS, Abdullahi A, Jadama L, Camara MM, Gaye PM, Mendy M, Davis N, Tiono AB, D’Alessandro U, Drakeley C, Bousema T, Moreno M, Collins KA. Malar J. 2021 Apr 20;20(1):191. doi: 10.1186/s12936-021-03725-y. PMID: 33879163

Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses.

Remarque EJ, Faber BW, Rodriguez Garcia R, Oostermeijer H, Sirima SB, Nebie Ouedraogo I, Kara L, Launay O, Houard S, Leroy O, Kocken CHM.NPJ Vaccines. 2021 Apr 14;6(1):55. doi: 10.1038/s41541-021-00319-2.PMID: 33854065 Free PMC article.

G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials.

Sepúlveda N, Grignard L, Curry J, Mahey L, Bastiaens GJH, Tiono AB, Okebe J, Coulibaly SA, Gonçalves BP, Affara M, Ouédraogo A, Bougouma EC, Sanou GS, Nébié I, Lanke K, Sirima SB, Dicko A, d’Alessandro U, Clark TG, Campino S, Chen I, Eziefula AC, Gosling R, Bousema T, Drakeley C. Front Genet. 2021 Apr 9;12:645688. doi: 10.3389/fgene.2021.645688. eCollection 2021. PMID: 33897764

Malaria is a cause of iron deficiency in African children.

Muriuki JM, Mentzer AJ, Mitchell R, Webb EL, Etyang AO, Kyobutungi C, Morovat A, Kimita W, Ndungu FM, Macharia AW, Ngetsa CJ, Makale J, Lule SA, Musani SK, Raffield LM, Cutland CL, Sirima SB, Diarra A, Tiono AB, Fried M, Gwamaka M, Adu-Afarwuah S, Wirth JP, Wegmüller R, Madhi SA, Snow RW, Hill AVS, Rockett KA, Sandhu MS, Kwiatkowski DP, Prentice AM, Byrd KA, Ndjebayi A, Stewart CP, Engle-Stone R, Green TJ, Karakochuk CD, Suchdev PS, Bejon P, Duffy PE, Davey Smith G, Elliott AM, Williams TN, Atkinson SH.Nat Med. 2021 Apr;27(4):653-658. doi: 10.1038/s41591-021-01238-4. Epub 2021 Feb 22.PMID: 33619371 Free PMC article.

Protocol for a quasi-experimental study to assess the feasibility, acceptability and costs of multiple first-lines artemisinin-based combination therapies for uncomplicated malaria in the Kaya health district, Burkina Faso.

Siribie M, Tchouatieu AM, Soulama I, Kaboré JMT, Nombré Y, Hien D, Kiba Koumaré A, Barry N, Baguiya A, Héma A, Dianda F, Savadogo Y, Kouanda S, Tiono AB, Sirima SB.BMJ Open. 2021 Feb 15;11(2):e040220. doi: 10.1136/bmjopen-2020-040220.PMID: 33589447 Free PMC article.

2020

Safety and immunogenicity of co-administration of meningococcal type A and measles-rubella vaccines with typhoid conjugate vaccine in children aged 15-23 months in Burkina Faso.

Sirima SB, Ouedraogo A, Barry N, Siribie M, Tiono AB, Nébié I, Konaté AT, Berges GD, Diarra A, Ouedraogo M, Soulama I, Hema A, Datta S, Liang Y, Rotrosen ET, Tracy JK, Jamka LP, Neuzil KM, Laurens MB.Int J Infect Dis. 2021 Jan;102:517-523. doi: 10.1016/j.ijid.2020.10.103. Epub 2020 Nov 8.PMID: 33176205 Free PMC article. Clinical Trial.

Estimating Annual Fluctuations in Malaria Transmission Intensity and in the Use of Malaria Control Interventions in Five Sub-Saharan African Countries.

RTS,S Epidemiology EPI-MAL-005 Study Group The RTS,S Epidemiology EPI-MAL-005 Study Group Is Composed Of Per Alphabetical Order, Adeniji E, Asante KP, Boahen O, Compaoré G, Coulibaly B, Kaali S, Kabore Y, Lamy M, Lusingu J, Malabeja A, Mens P, Orsini M, Otieno L, Otieno W, Owusu-Agyei S, Oyieko J, Pirçon JY, Praet N, Roman F, Sie A, Sing’oei V, Sirima SB, Sylla K, Tine R, Tiono AB, Tivura M, Usuf E, Wéry S.Am J Trop Med Hyg. 2020 Nov;103(5):1883-1892. doi: 10.4269/ajtmh.19-0795.

Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria.

Dieng MM, Diawara A, Manikandan V, Tamim El Jarkass H, Sermé SS, Sombié S, Barry A, Coulibaly SA, Diarra A, Drou N, Arnoux M, Yousif A, Tiono AB, Sirima SB, Soulama I, Idaghdour Y.Nat Commun. 2020 Oct 9;11(1):5093. doi: 10.1038/s41467-020-18915-6.PMID: 33037226 Free PMC article.

Malaria is a cause of iron deficiency in African children.

Muriuki JM, Mentzer AJ, Mitchell R, Webb EL, Etyang AO, Kyobutungi C, Morovat A, Kimita W, Ndungu FM, Macharia AW, Ngetsa CJ, Makale J, Lule SA, Musani SK, Raffield LM, Cutland CL, Sirima SB, Diarra A, Tiono AB, Fried M, Gwamaka M, Adu-Afarwuah S, Wirth JP, Wegmüller R, Madhi SA, Snow RW, Hill AVS, Rockett KA, Sandhu MS, Kwiatkowski DP, Prentice AM, Byrd KA, Ndjebayi A, Stewart CP, Engle-Stone R, Green TJ, Karakochuk CD, Suchdev PS, Bejon P, Duffy PE, Davey Smith G, Elliott AM, Williams TN, Atkinson SH.Nat Med. 2021 Apr;27(4):653-658. doi: 10.1038/s41591-021-01238-4. Epub 2021 Feb 22.PMID: 33619371 Free PMC article

PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study.

Sirima SB, Richert L, Chêne A, Konate AT, Campion C, Dechavanne S, Semblat JP, Benhamouda N, Bahuaud M, Loulergue P, Ouédraogo A, Nébié I, Kabore M, Kargougou D, Barry A, Ouattara SM, Boilet V, Allais F, Roguet G, Havelange N, Lopez-Perez E, Kuppers A, Konaté E, Roussillon C, Kanté M, Belarbi L, Diarra A, Henry N, Soulama I, Ouédraogo A, Esperou H, Leroy O, Batteux F, Tartour E, Viebig NK, Thiebaut R, Launay O, Gamain B.Lancet Infect Dis. 2020 May;20(5):585-597. doi: 10.1016/S1473-3099(19)30739-X. Epub 2020 Feb 4.PMID: 32032566 Free article. Clinical Trial.

Estimating the burden of iron deficiency among African children.

Muriuki JM, Mentzer AJ, Webb EL, Morovat A, Kimita W, Ndungu FM, Macharia AW, Crane RJ, Berkley JA, Lule SA, Cutland C, Sirima SB, Diarra A, Tiono AB, Bejon P, Madhi SA, Hill AVS, Prentice AM, Suchdev PS, Elliott AM, Williams TN, Atkinson SH.BMC Med. 2020 Feb 27;18(1):31. doi: 10.1186/s12916-020-1502-7.PMID: 32102669 Free PMC article.

Antibody response to Schistosoma haematobium and other helminth species in malaria-exposed populations from Burkina Faso.

Mangano VD, Bianchi C, Ouedraogo M, Kabore Y, Corran P, Silva N, Sirima SB, Nebie I, Bruschi F, Modiano D.Acta Trop. 2020 May;205:105381. doi: 10.1016/j.actatropica.2020.105381. Epub 2020 Jan 30.PMID: 32007449