2022-2021

2022

African-specific polymorphisms in Plasmodium falciparum serine repeat antigen 5 in Uganda and Burkina Faso clinical samples do not interfere with antibody response to BK-SE36 vaccination.

Arisue N, Palacpac NMQ, Ntege EH, Yeka A, Balikagala B, Kanoi BN, Bougouma EC, Tiono AB, Nebie I, Diarra A, Houard S, D’Alessio F, Leroy O, Sirima SB, Egwang TG, Horii T.Front Cell Infect Microbiol. 2022 Dec 16;12:1058081. doi: 10.3389/fcimb.2022.1058081. eCollection 2022.PMID: 36590593 Free PMC article.

Impact of exposure to malaria and nutritional status on responses to the experimental malaria vaccine ChAd63 MVA ME-TRAP in 5-17 month-old children in Burkina Faso.

Morter R, Tiono AB, Nébié I, Hague O, Ouedraogo A, Diarra A, Viebig NK, Hill AVS, Ewer KJ, Sirima SB.Front Immunol. 2022 Dec 2;13:1058227. doi: 10.3389/fimmu.2022.1058227. eCollection 2022.PMID: 36532031 Free PMC article. Clinical Trial.

A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria.

Sirima SB, Ouédraogo A, Tiono AB, Kaboré JM, Bougouma EC, Ouattara MS, Kargougou D, Diarra A, Henry N, Ouédraogo IN, Billingsley PF, Manoj A, Abebe Y, Kc N, Ruben A, Richie TL, James ER, Joshi S, Shrestha B, Strauss K, Lyke KE, Plowe CV, Potter GE, Cox C, Jones W, Sim BKL, Hoffman SL, Laurens MB.Sci Transl Med. 2022 Dec 7;14(674):eabj3776. doi: 10.1126/scitranslmed.abj3776. Epub 2022 Dec 7.PMID: 36475905 Clinical Trial.

Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy.

Kc N, Church LWP, Riyahi P, Chakravarty S, Seder RA, Epstein JE, Lyke KE, Mordmüller B, Kremsner PG, Sissoko MS, Healy S, Duffy PE, Jongo SA, Nchama VUNN, Abdulla S, Mpina M, Sirima SB, Laurens MB, Steinhardt LC, Oneko M, Li M, Murshedkar T, Billingsley PF, Sim BKL, Richie TL, Hoffman SL.Front Immunol. 2022 Oct 25;13:1006716. doi: 10.3389/fimmu.2022.1006716. eCollection 2022.PMID: 36389797 Free PMC article.

Editorial: Understanding the materno-fetal interface during microbial infections, Volume II.

Sarr D, Fretes RE, Kemmerling U, Sirima SB.Front Microbiol. 2022 Oct 28;13:1072491. doi: 10.3389/fmicb.2022.1072491. eCollection 2022.PMID: 36386668 Free PMC article. No abstract available.

Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children.

Bougouma EC, Palacpac NMQ, Tiono AB, Nebie I, Ouédraogo A, Houard S, Yagi M, Coulibaly SA, Diarra A, Tougan T, Ouedraogo AZ, Soulama I, Arisue N, Yaro JB, D’Alessio F, Leroy O, Cousens S, Horii T, Sirima SB.Front Immunol. 2022 Aug 31;13:978591. doi: 10.3389/fimmu.2022.978591. eCollection 2022.PMID: 36119062 Free PMC article. Clinical Trial.

Seasonal Malaria Chemoprevention Implementation: Effect on Malaria Incidence and Immunity in a Context of Expansion of P. falciparum Resistant Genotypes with Potential Reduction of the Effectiveness in Sub-Saharan Africa.

Nikiema S, Soulama I, Sombié S, Tchouatieu AM, Sermé SS, Henry NB, Ouedraogo N, Ouaré N, Ily R, Ouédraogo O, Zongo D, Djigma FW, Tiono AB, Sirima SB, Simporé J.Infect Drug Resist. 2022 Aug 13;15:4517-4527. doi: 10.2147/IDR.S375197. eCollection 2022.PMID: 35992756 Free PMC article. Review.

Stakeholder perceptions on the deployment of multiple first-line therapies for uncomplicated malaria: a qualitative study in the health district of Kaya, Burkina Faso.

Hien D, Kaboré JMT, Siribié M, Soulama I, Barry N, Baguiya A, Tiono AB, Tchouatieu AM, Sirima SB.Malar J. 2022 Jun 27;21(1):202. doi: 10.1186/s12936-022-04225-3.PMID: 35761273 Free PMC article.

NK Cell Subset Redistribution and Antibody Dependent Activation after Ebola Vaccination in Africans.

Wagstaffe HR, Anzala O, Kibuuka H, Anywaine Z, Sirima SB, Thiébaut R, Richert L, Levy Y, Lacabaratz C, Bockstal V, Luhn K, Douoguih M, Goodier MR.Vaccines (Basel). 2022 May 31;10(6):884. doi: 10.3390/vaccines10060884.PMID: 35746491 Free PMC article.

GMZ2 Vaccine-Induced Antibody Responses, Naturally Acquired Immunity and the Incidence of Malaria in Burkinabe Children.

Dassah S, Adu B, Tiendrebeogo RW, Singh SK, Arthur FKN, Sirima SB, Theisen M.Front Immunol. 2022 Jun 2;13:899223. doi: 10.3389/fimmu.2022.899223. eCollection 2022.PMID: 35720297 Free PMC article.

Attitudes, practices, and determinants of community care-seeking behaviours for fever/malaria episodes in the context of the implementation of multiple first-line therapies for uncomplicated malaria in the health district of Kaya, Burkina Faso.

Kaboré JMT, Siribié M, Hien D, Soulama I, Barry N, Nombré Y, Dianda F, Baguiya A, Tiono AB, Burri C, Tchouatieu AM, Sirima SB.Malar J. 2022 May 30;21(1):155. doi: 10.1186/s12936-022-04180-z.PMID: 35637506 Free PMC article.

Vitamin D Deficiency and Its Association with Iron Deficiency in African Children.

Mogire RM, Muriuki JM, Morovat A, Mentzer AJ, Webb EL, Kimita W, Ndungu FM, Macharia AW, Cutland CL, Sirima SB, Diarra A, Tiono AB, Lule SA, Madhi SA, Prentice AM, Bejon P, Pettifor JM, Elliott AM, Adeyemo A, Williams TN, Atkinson SH.Nutrients. 2022 Mar 25;14(7):1372. doi: 10.3390/nu14071372.PMID: 35405984 Free PMC article.

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in children and adolescents in Africa: A randomised, placebo-controlled, multicentre Phase II clinical trial.

Anywaine Z, Barry H, Anzala O, Mutua G, Sirima SB, Eholie S, Kibuuka H, Bétard C, Richert L, Lacabaratz C, McElrath MJ, De Rosa SC, Cohen KW, Shukarev G, Katwere M, Robinson C, Gaddah A, Heerwegh D, Bockstal V, Luhn K, Leyssen M, Thiébaut R, Douoguih M; EBL2002 Study group.PLoS Med. 2022 Jan 11;19(1):e1003865. doi: 10.1371/journal.pmed.1003865. eCollection 2022 Jan.PMID: 35015777 Free PMC article. Clinical Trial.

2021

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in children and adolescents in Africa: A randomised, placebo-controlled, multicentre Phase II clinical trial.

Anywaine Z, Barry H, Anzala O, Mutua G, Sirima SB, Eholie S, Kibuuka H, Bétard C, Richert L, Lacabaratz C, McElrath MJ, De Rosa SC, Cohen KW, Shukarev G, Katwere M, Robinson C, Gaddah A, Heerwegh D, Bockstal V, Luhn K, Leyssen M, Thiébaut R, Douoguih M; EBL2002 Study group. PLoS Med. 2022 Jan 11;19(1):e1003865. doi: 10.1371/journal.pmed.1003865. eCollection 2022 Jan. PMID: 35015777

Risk factors associated with house entry of malaria vectors in an area of Burkina Faso with high, persistent malaria transmission and high insecticide resistance.

Yaro JB, Tiono AB, Sanou A, Toe HK, Bradley J, Ouedraogo A, Ouedraogo ZA, Guelbeogo MW, Agboraw E, Worrall E, Sagnon N’, Lindsay SW, Wilson AL. Malar J. 2021 Oct 10;20(1):397. doi: 10.1186/s12936-021-03926-5. PMID: 34629053

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in healthy and HIV-infected adults: A randomised, placebo-controlled Phase II clinical trial in Africa.

Barry H, Mutua G, Kibuuka H, Anywaine Z, Sirima SB, Meda N, Anzala O, Eholie S, Bétard C, Richert L, Lacabaratz C, McElrath MJ, De Rosa S, Cohen KW, Shukarev G, Robinson C, Gaddah A, Heerwegh D, Bockstal V, Luhn K, Leyssen M, Douoguih M, Thiébaut R; EBL2002 Study group. PLoS Med. 2021 Oct 29;18(10):e1003813. doi: 10.1371/journal.pmed.1003813. eCollection 2021 Oct. PMID: 34714820

Risk factors for Plasmodium falciparum infection in pregnant women in Burkina Faso: a community-based cross-sectional survey.

Yaro JB, Ouedraogo A, Diarra A, Sombié S, Ouedraogo ZA, Nébié I, Drakeley C, Sirima SB, Tiono AB, Lindsay SW, Wilson AL.Malar J. 2021 Sep 6;20(1):362. doi: 10.1186/s12936-021-03896-8.PMID: 34488770 Free PMC article.

Persistent Submicroscopic Plasmodium falciparum Parasitemia 72 Hours after Treatment with Artemether-Lumefantrine Predicts 42-Day Treatment Failure in Mali and Burkina Faso.

Beshir KB, Diallo N, Somé FA, Sombie S, Zongo I, Fofana B, Traore A, Dama S, Bamadio A, Traore OB, Coulibaly SA, Maurice OS, Diarra A, Kaboré JM, Kodio A, Togo AH, Dara N, Coulibaly M, Dao F, Nikiema F, Compaore YD, Kabore NT, Barry N, Soulama I, Sagara I, Sirima SB, Ouédraogo JB, Djimde A, Sutherland CJ.Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0087321. doi: 10.1128/AAC.00873-21. Epub 2021 Jul 16.PMID: 34060901

Extended follow-up of children in a phase2b trial of the GMZ2 malaria vaccine.

Dassah S, Adu B, Sirima SB, Mordmüller B, Ngoa UA, Atuguba F, Arthur FKN, Mensah BA, Kaddumukasa M, Bang P, Kremsner PG, Mategula D, Flach C, Milligan P, Theisen M.Vaccine. 2021 Jul 13;39(31):4314-4319. doi: 10.1016/j.vaccine.2021.06.024. Epub 2021 Jun 24.PMID: 34175127 Free article. Clinical Trial.

Safety and immunogenicity of Vi-typhoid conjugate vaccine co-administration with routine 9-month vaccination in Burkina Faso: A randomized controlled phase 2 trial.

Sirima SB, Ouedraogo A, Barry N, Siribie M, Tiono A, Nébié I, Konaté A, Berges GD, Diarra A, Ouedraogo M, Bougouma EC, Soulama I, Hema A, Datta S, Liang Y, Rotrosen ET, Tracy JK, Jamka LP, Oshinsky JJ, Pasetti MF, Neuzil KM, Laurens MB. Int J Infect Dis. 2021 Jul;108:465-472. doi: 10.1016/j.ijid.2021.05.061. Epub 2021 Jun 1. PMID: 34082090

Prevalence and predictors of vitamin D deficiency in young African children.

Mogire RM, Morovat A, Muriuki JM, Mentzer AJ, Webb EL, Kimita W, Ndungu FM, Macharia AW, Cutland CL, Sirima SB, Diarra A, Tiono AB, Lule SA, Madhi SA, Sandhu MS, Prentice AM, Bejon P, Pettifor JM, Elliott AM, Adeyemo A, Williams TN, Atkinson SH.BMC Med. 2021 May 20;19(1):115. doi: 10.1186/s12916-021-01985-8.PMID: 34011341 Free PMC article.

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.

Adoke Y, Zoleko-Manego R, Ouoba S, Tiono AB, Kaguthi G, Bonzela JE, Duong TT, Nahum A, Bouyou-Akotet M, Ogutu B, Ouedraogo A, Macintyre F, Jessel A, Laurijssens B, Cherkaoui-Rbati MH, Cantalloube C, Marrast AC, Bejuit R, White D, Wells TNC, Wartha F, Leroy D, Kibuuka A, Mombo-Ngoma G, Ouattara D, Mugenya I, Phuc BQ, Bohissou F, Mawili-Mboumba DP, Olewe F, Soulama I, Tinto H; FALCI Study Group. Malar J. 2021 May 19;20(1):222. doi: 10.1186/s12936-021-03749-4. PMID: 34011358

Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections.

Barry A, Bradley J, Stone W, Guelbeogo MW, Lanke K, Ouedraogo A, Soulama I, Nébié I, Serme SS, Grignard L, Patterson C, Wu L, Briggs JJ, Janson O, Awandu SS, Ouedraogo M, Tarama CW, Kargougou D, Zongo S, Sirima SB, Marti M, Drakeley C, Tiono AB, Bousema T.Nat Commun. 2021 Apr 26;12(1):2443. doi: 10.1038/s41467-021-22573-7.PMID: 33903595 Free PMC article.

Maintaining Plasmodium falciparum gametocyte infectivity during blood collection and transport for mosquito feeding assays in the field.

Soumare HM, Guelbeogo WM, van de Vegte-Bolmer M, van Gemert GJ, Soumanaba Z, Ouedraogo A, Ouattara MS, Abdullahi A, Jadama L, Camara MM, Gaye PM, Mendy M, Davis N, Tiono AB, D’Alessandro U, Drakeley C, Bousema T, Moreno M, Collins KA. Malar J. 2021 Apr 20;20(1):191. doi: 10.1186/s12936-021-03725-y. PMID: 33879163

Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses.

Remarque EJ, Faber BW, Rodriguez Garcia R, Oostermeijer H, Sirima SB, Nebie Ouedraogo I, Kara L, Launay O, Houard S, Leroy O, Kocken CHM.NPJ Vaccines. 2021 Apr 14;6(1):55. doi: 10.1038/s41541-021-00319-2.PMID: 33854065 Free PMC article.

G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials.

Sepúlveda N, Grignard L, Curry J, Mahey L, Bastiaens GJH, Tiono AB, Okebe J, Coulibaly SA, Gonçalves BP, Affara M, Ouédraogo A, Bougouma EC, Sanou GS, Nébié I, Lanke K, Sirima SB, Dicko A, d’Alessandro U, Clark TG, Campino S, Chen I, Eziefula AC, Gosling R, Bousema T, Drakeley C. Front Genet. 2021 Apr 9;12:645688. doi: 10.3389/fgene.2021.645688. eCollection 2021. PMID: 33897764

Malaria is a cause of iron deficiency in African children.

Muriuki JM, Mentzer AJ, Mitchell R, Webb EL, Etyang AO, Kyobutungi C, Morovat A, Kimita W, Ndungu FM, Macharia AW, Ngetsa CJ, Makale J, Lule SA, Musani SK, Raffield LM, Cutland CL, Sirima SB, Diarra A, Tiono AB, Fried M, Gwamaka M, Adu-Afarwuah S, Wirth JP, Wegmüller R, Madhi SA, Snow RW, Hill AVS, Rockett KA, Sandhu MS, Kwiatkowski DP, Prentice AM, Byrd KA, Ndjebayi A, Stewart CP, Engle-Stone R, Green TJ, Karakochuk CD, Suchdev PS, Bejon P, Duffy PE, Davey Smith G, Elliott AM, Williams TN, Atkinson SH.Nat Med. 2021 Apr;27(4):653-658. doi: 10.1038/s41591-021-01238-4. Epub 2021 Feb 22.PMID: 33619371 Free PMC article.

Protocol for a quasi-experimental study to assess the feasibility, acceptability and costs of multiple first-lines artemisinin-based combination therapies for uncomplicated malaria in the Kaya health district, Burkina Faso.

Siribie M, Tchouatieu AM, Soulama I, Kaboré JMT, Nombré Y, Hien D, Kiba Koumaré A, Barry N, Baguiya A, Héma A, Dianda F, Savadogo Y, Kouanda S, Tiono AB, Sirima SB.BMJ Open. 2021 Feb 15;11(2):e040220. doi: 10.1136/bmjopen-2020-040220.PMID: 33589447 Free PMC article.